SPRAVATO®
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SPRAVATO® is the first FDA-approved nasal spray for adults with treatment-resistant depression and major depressive disorder. Esketamine is administered in a certified treatment center under the supervision of a certified healthcare provider.
Treatment-resistant depression (TRD) is a term most commonly used in clinical psychiatry to describe cases of depressive disorders, such as Major Depressive Disorder and Bipolar Disorders, that do not respond adequately to at least two antidepressants. In the last 20 years, research has consistently shown that low doses of ketamine can rapidly relieve depressive symptoms in patients whose depression has been otherwise resistant to treatment.
Ketamine therapy is very effective on the following types of depression:
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Bipolar Depression (BPD)
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Depression from Traumatic Brain Injury (TBI)
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Anxiety Disorders


We delight in the beauty of the butterfly, and rarely admit the changes it has gone through to achieve the beauty ~ Maya Angelou
What is Spravato?
SPRAVATO® is a ketamine-based prescription nasal spray that is taken along with an oral antidepressant. It increases glutamate, a naturally occurring chemical in the brain that helps transmit messages between brain cells. When glutamate increases, communication between brain cells improves, positively affecting mood.
Studies show those who took Esketamie Nasal Spray experienced more significant reductions in depression symptoms at four weeks compared to those who received a placebo plus an oral antidepressant. SPRAVATO® works quickly and has a high success rate, giving new hope to those who have not found relief from their current depression prescription and treatment plans.

“The richest and fullest lives attempt to achieve an inner balance between three realms: love, work, and play.”
~ Erik Erikson
SPRAVATO® (nasal esketamine) is chemically similar to ketamine and is offered in a nasal spray version as an in-office treatment. It is FDA-approved and covered by insurance, and a savings plan is available for the co-payments. You can also contact SPRAVATO withMe to enroll by calling 844-479-4846.


Because SPRAVATO® is a psychedelic treatment medication, it must be taken as an outpatient in a certified facility. Behavioral Health Resiliency PLLC is an accredited Risk Evaluation and Mitigation Strategy (REMS) program specially trained to monitor the use of SPRAVATO®. Under the instruction of the health care provider, you will administer the nasal spray to yourself.
Wondering what to expect? See more here. You remain in the office for about 2 hours. You will be monitored and cared for, including monitoring you for any side effects.
Treatments are provided twice weekly for four weeks, weekly for four weeks, then weekly/every other week before a tapering course (at least four months of treatment); treatments last a minimum of two hours.
Why Spravato?
Is it right for you?
If you've been struggling with depression and traditional treatments haven't provided the relief you need, you're not alone. Treatment-resistant depression occurs when symptoms persist or return despite trying multiple antidepressants and psychotherapy. It's important to note that Spravato is not a first-line treatment for depression and should only be considered after other options have been exhausted.
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Good Enough is not Good Enough, you can live a full authentic life and you deserve to live a full authentic life
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While treatment-resistant depression can be challenging, there are additional options available:
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Combination therapy: Combining different antidepressants or adding other medications.
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Augmentation therapy: Using additional medications to enhance the effectiveness of antidepressants.
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Ketamine: A newer treatment option that has shown promise for some individuals. This is not covered by most insurance plans.
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Electroconvulsive therapy (ECT): A medical procedure that involves inducing seizures with electrical stimulation.
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Transcranial magnetic stimulation (TMS): A non-invasive procedure that uses magnetic fields to stimulate areas of the brain.
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Spravato® (esketamine) is a nasal spray prescribed to adults dealing with treatment depression (TRD). This treatment can help those who haven't found relief with other medications. Here are some essential points to know about Spravato:
- Spravato® (esketamine) works differently from traditional antidepressants. Spravato® (esketamine) works by targeting a different receptor in the brain, which can provide rapid relief from depressive symptoms. If you've tried other antidepressants without success, Spravato® (esketamine) may be an option for you. However, it's crucial to complete a comprehensive assessment, as Spravato® (esketamine) is a controlled substance and requires medical supervision.
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Spravato® (esketamine) can provide relief from depressive symptoms within hours of the first dose, offering hope for those struggling with treatment-resistant depression.
- Spravato® (esketamine) has been shown to provide rapid relief. Many users may start to feel better within hours of their first dose.
- Spravato® (esketamine) is usually prescribed alongside an oral antidepressant for better results.
- Spravato® (esketamine) can only be obtained through a certified healthcare provider's office or clinic.
- Spravato treatment has been shown to have a lower risk of side effects compared to traditional antidepressants.
If you're facing challenges with TRD, lets see if Spravato may be right for you.
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Getting Started with Spravato
If you're considering Spravato as a treatment option for your treatment-resistant depression, here are the general steps involved:
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Schedule an appointment. Discuss your symptoms, treatment history, and the possibility of using Spravato.
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90 minute Initial Evaluation: We will assess your suitability for Spravato® (esketamine), including medical history, current medications, and potential risks. You must complete the portal history and consent to treat 24 hours before the appointment, or we will reschedule.
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If you are appropriate for Spravato® (esketamine) we will write a prescription. A Certified Pharmacy will manage this.
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Spravato® (esketamine) is only available through certified healthcare providers. Behavioral Health Resiliency PLLC is a Certified REMS Site
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You will need to complete the document to be enrolled in the Spravato® (esketamine) REMS Program
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Once you're enrolled in the Spravato REMS program and we have received the approval from your insurance, you'll be able to obtain the medication and undergo the necessary monitoring and support.
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The specific enrollment process may vary depending on your insurance.
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It's important to note that the exact process may vary depending on your individual circumstances.
If you have any questions or concerns about starting Spravato, schedule an appointment